Abstract
Actions of aminosulfonic acids (taurine, 1-amino-2-oxypropane-sulfonic acid, 1-methylamino-2-oxypropane-sulfonicacid, benzoylamino-oxypropane-sulfonicacid, betaine of sulfonic acid, betaine of 1-pyridyl-2-oxypropane-sulfonic acid, and sulfanilic acid) were examined on the blood-vessel of a frog's hind leg in comparison with that of aminocarbonic acids and of their derivatives (glycocoll, l-leucine, dl-leucine, l-tyrosine, histidine, arginine, isoserine, glycyl-glycine, glycine anhydride, hippuric acid, phenylhippuric acid, ornithuric acid, a-pyridinuric acid, and a-pyridinornithuric acid) and other chemically related compounds (creatine, creatinine, p-aminobenzoic acid, and diphenyloxyethylamine hydrochloride). Result : Aminosulfonic acids exerted generally weak dilatations on blood-vessels and contractions were seen only in the strong solutions. Aminocarbonic acids acted similarly very weakly, among which glycocoll, diglycine, arginine, etc. showed primarily dilation and then contraction. In the experiment on the epinephrine combination taurine, aminoxypropane-sulfonic acid and its methyl and benzoyl derivatives, betaine of sulfonic acid, betaine of pyridyloxypropane-sulfonic acid, etc. inhibited the epinephrine action on blood-vessels.
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