Abstract
Reduction of the wound healing time after surgical procedures along with good hemostasis, and the reduction of post-surgical edema, pain and infective complications are generally desirable to both clinicians and patients. Recently, a gel compound containing sodium hyaluronate and four synthetic aminoacids (glycine, leucine, proline, lysine) and marketed as Aminogam® (Errekappa Euroterapici, Italy), has been proposed as a medical device promoting faster wound healing after oral surgery procedures. To assess its achievable clinical benefits, we studied retrospectively 580 cases (290 study cases and 290 control cases) undergoing oral surgery and receiving Aminogam ® gel application. More precisely, cases were divided into 7 groups on the bases of the kind of surgery (teeth extraction, oral surgery in patients taking bisphosphonates, surgical treatment of jaw osteonecrosis related to bisphosphonates therapy, placement of endosseous implants, diode laser surgery of oral mucosa lesions with second intention healing without stitches, diode laser photocoagulation of slow flow vascular malformations and bone surgery). In all instances, Aminogam® gel was applied at least five times a day until the wound healed completely. We compared the elapsed time between surgery and complete healing with Aminogam® application compared to control cases receiving no other drug treatment. Our results confirmed that the overall time of healing is certainly reduced in cases receiving Aminogam® gel regardless of the kind of oral surgery.
Highlights
The reduction of the wound healing time along with reduction of infective complications, good hemostasis and the reduction of the post-surgical edema and pain are certainly desirable to bothAppl
Wound healing is a specific and crucial biological process characterized by consecutive phases starting with angiogenesis and followed by fibroblast proliferation and differentiation, deposition of the extracellular matrix (ECM) and final re-epithelialization [1,2,3]
The statistical analysis showed that healing time (HT) was consistently shorter in all cases treated with Aminogam gel (p < 0.001) regardless the kind of surgery
Summary
The reduction of the wound healing time along with reduction of infective complications, good hemostasis and the reduction of the post-surgical edema and pain are certainly desirable to bothAppl. The reduction of the wound healing time along with reduction of infective complications, good hemostasis and the reduction of the post-surgical edema and pain are certainly desirable to both. Sci. 2020, 10, 1105 clinicians and patients. Wound healing is a specific and crucial biological process characterized by consecutive phases starting with angiogenesis and followed by fibroblast proliferation and differentiation, deposition of the extracellular matrix (ECM) and final re-epithelialization [1,2,3]. Fibroblasts and macrophages are both involved in the healing process. Fibroblasts promote neo-angiogenesis, secrete all ECM components (glycosaminoglycans, proteoglycans, glycoproteins and collagens) and produce several cytokines and growth factors [4]. Macrophages digest and kill bacterial pathogens, clean tissue debris and secrete a variety of chemotactic and growth factors [5,6]
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