Abstract
Lithium aminoborohydrides (LAB), obtained by the reaction of n-butyllithium with amineboranes, are powerful reducing agents for a wide range of functional groups including the carbonyl group of alkylcyclohexanones. Reduction of 2-methylcyclohexanone with LAB reagents shows superior formation of the axial alcohol as compared to sodium borohydride (NaBH4). Reduction of 3- and 4-methylcyclohexanones shows formation of the equatorial alcohol in proportions similar to that obtained with NaBH4. Reduction of 4-tert-butylcyclohexanone leads predominantly to the corresponding cyclohexanol containing an equatorial alcohol group. Unlike NaBH4, LAB reagents are soluble in ether solvents allowing for homogeneous reductions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
