Abstract
Y. Samejima, Y. Aoki and D. Mebs. Amino acid sequence of a myotoxin from venom of the eastern diamondback rattlesnake ( Crotalus adamanteus). Toxicon 29, 461–468, 1991.—The complete amino acid sequence of a myotoxin isolated from Crotalus adamanteus venom (CAM-toxin) was determined. The total number of amino acid residues was 45, giving a mol. wt of 5202. The amino acid sequence was compared with those of previously determined Crotalus myotoxins. The CAM-toxin shows a surprisingly close relationship to those of peptide c ( C. v. helleri), myotoxin a ( C. v. viridis), crotamine ( C. d. terrificus), myotoxin I and II ( C. v. concolor) with homologies of approximately 98, 83, 90, 95 and 91%, respectively. The hydropathy profile of the CAM-toxin is almost identical to peptide c and myotoxin I, as can be assumed from the sequence homology. Despite the absence of any close sequence homology with the myotoxic phospholipase A 2 enzymes, CAM-toxin contains a similar cationic myotoxic region at residues 2–10 as found in the other five myotoxic peptides.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
