Abstract
Loss of free amino acids during hemodiafiltration therapy was investigated in 5 dogs. Hemodiafiltration was performed with a cellulose-acetate membrane with a limit of molecular separation at MW 19,000. The concentration of amino acids was investigated in ultrafiltrate and in blood at the beginning and at the end of diafiltration. Loss of amino acids in the ultrafiltrate was seven times as much as free amino acid content of plasma, whereas amino acid concentration in plasma decreased only slightly (20%). Applying these results to hemodiafiltration in man, it is concluded that loss of amino acids in hemodiafiltration is not greater than in conventional hemodialysis therapy.
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