Abstract
Different in vitro and in silico approaches from our research group have demonstrated that neutral electrolyzed water (NEW) can be used to detoxify aflatoxins. The objective of this investigation was to evaluate the ability of NEW to detoxify B-aflatoxins (AFB1 and AFB2) in contaminated maize and to confirm detoxification in an in vivo experimental model. Batches of aflatoxin-contaminated maize were detoxified with NEW and mixed in commercial feed. A total of 240 6-day-old female large white Nicholas-700 turkey poults were randomly divided into four treatments of six replicates each (10 turkeys per replicate), which were fed ad libitum for two weeks with the following dietary treatments: (1) control feed containing aflatoxin-free maize (CONTROL); (2) feed containing the aflatoxin-contaminated maize (AF); (3) feed containing the aflatoxin-contaminated maize detoxified with NEW (AF + NEW); and (4) control feed containing aflatoxin-free maize treated with NEW (NEW). Compared to the control groups, turkey poults of the AF group significantly reduced body weight gain and increased feed conversion ratio and mortality rate; whereas turkey poults of the AF + NEW group did not present significant differences on productive parameters. In addition, alterations in serum biochemical constituents, enzyme activities, relative organ weight, gross morphological changes and histopathological studies were significantly mitigated by the aflatoxin-detoxification procedure. From these results, it is concluded that the treatment of aflatoxin-contaminated maize with NEW provided reasonable protection against the effects caused by aflatoxins in young turkey poults.
Highlights
Among the many types of microorganisms that cause food-borne disease outbreaks, toxigenic fungi and their products threaten the health and economy of the poultry industry by contaminating feed materials [1,2,3,4]
Regarding the main physicochemical properties of neutral electrolyzed water (NEW), after electrolysis and up to the end of the high level of available chlorine concentration (ACC), which is totally dependent on the electrolysis conditions
Ultraviolet spectrum demonstrated two absorption the high level of ACC, which is totally dependent on the electrolysis conditions
Summary
Among the many types of microorganisms that cause food-borne disease outbreaks, toxigenic fungi and their products (mycotoxins) threaten the health and economy of the poultry industry by contaminating feed materials [1,2,3,4]. Developing strategies to detoxify mycotoxin contamination is crucial for the food and animal feed industries. A diversified portfolio of strategies to detoxify food and feed has been proposed to reduce the adverse effects of aflatoxin contamination, including physical selection of the contaminated commodity, thermal inactivation, irradiation and supplementation with nano-clay adsorbent, biological degradation by microbial fermentation, and chemical treatment with acids, bases, organic solvents, and gases [1,15]. The purpose of this study was to evaluate the ability of NEW to detoxify B-aflatoxins in contaminated maize and confirm detoxification in turkey poults
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