Abstract
The brain is kept buoyant by cerebrospinal fluid (CSF). This buoyancy is critical for the brain to function normally. In older age, and under certain conditions, when the brain begins to lose full buoyancy, it sets in motion a compensatory mechanism to maintain buoyancy. And this compensatory mechanism involves the production of a globular colloid-like protein, in the form of amyloid plaques, to act as a volume expander, much in the same way serum albumin acts to maintain oncotic pressure and hold water in the intravascular space. As all compensatory mechanisms have a limit, buoyancy is ultimately compromised and leads to impaired CSF flow dynamics in a predictable, gravity dependent manner. This CSF stasis, or impaired clearance, leads to Alzheimer’s Disease (AD), as chronic gravity acts as a constant pathologic force.
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