Abstract
A broad range of aliphatic, alicyclic, and aromatic ketones and aldehydes underwent smooth reduction with a combination of common, inexpensive laboratory reagents, sodium borohydride and chromatographic neutral alumina, in hexane to afford the corresponding alcohols in a selective and high-yielding manner under mild and neutral conditions. The NaBH4-based biphasic system can also successfully be used for the reduction of unsaturated substrates as well as steroidal and highly hindered ketones.
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