Abstract
Alternative methanogenesis - Methanogenic potential of organosulfur administration.
Highlights
Mammalian methanogenesis is principally linked to carbohydrate fermentation by the anaerobic intestinal microflora [1], but alternative pathways for non-bacterial methane (CH4) generation have been described in aerobic living systems [2, 3]
In Groups 2 and 3 (n = 7, each) the animals received standard laboratory chow enriched with 10% mustard-seed for 7 days or 14 days, respectively
DMSO is a potent CH4 donor molecule in the presence of reactive oxygen species (ROS) generation [4, 5] Methanogenesis in vitro was promptly induced in the DMSO-containing tubes (10925±3139 ppm) while lower CH4 emission was detected in the DMSO+DMTU-containing tubes (6954±784 ppm; p = 0.164 vs DMSO)
Summary
Mammalian methanogenesis is principally linked to carbohydrate fermentation by the anaerobic intestinal microflora [1], but alternative pathways for non-bacterial methane (CH4) generation have been described in aerobic living systems [2, 3] In this respect it has been shown that aerobic CH4 can be readily formed from organosulfur compounds at ambient atmospheric pressure and temperature in vitro [4]. While CH4 is conventionally believed to be physiologically inert, anti-inflammatory effects were described for exogenous CH4 in several experimental hypoxia-reoxygenation conditions [8] These and other data collectively raised the possibility that non-bacterial CH4 emissions can be part of an adaptive response to oxido-reductive stress in eukaryotes [6, 7]
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