Abstract
Studies of human patients with thrombohemorrhagic phenomena demonstrate that a wide range of coagulation and fibrinolytic changes may be manifested under disease conditions. Injection of thrombotic agents or fibrinolytic activators into animals shows this same broad spectrum of changes under experimental situations. The most important studies in diagnosing these thrombohemorrhagic phenomena are platelets, factor v, fibrinogen and profibrinolysin. Where the condition is predominantly intravascular coagulation, platelets will be severely depressed, factor v is moderately low, fibrinogen moderately or extremely depleted but profibrinolysin only minimally decreased. In conditions that are predominantly fibrinolytic in nature, platelets may be somewhat low; factor v will be severely depleted; fibrinogen may again be either moderately or extremely depressed; and levels of profibrinolysin will be very low due to activation of this enzyme precursor.
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