Abstract
The adhesion of platelets to glass has been quantitated in control subjects and in patients with vascular disease, diabetes mellitus, uremia, disorders of the prostate gland, or congenital deficiency of certain blood coagulation factors. Platelet adhesion was quantitated by means of a simple in vitro test which permits differentiation of adhesion from aggregation. Platelet adhesion was elevated above control values in patients with vascular diseases who were not taking anticoagulants. Decreased platelet adhesion occurred in patients with uremia and in four of five patients with disorders of the prostate gland. Marked variation in platelet adhesion values was found in diabetic patients and in patients with vascular diseases who were taking anticoagulants. Patients deficient in coagulation factors V, VIII, IX, X, or XII had normal platelet adhesion values.
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