Abstract
Orexin-A well-known as hypocretin-1 is a neuropeptide that is produced in the lateral hypothalamus area (LHA). It promotes widespread cortical activation. In this study, the effect of SB-334867 as OX1R antagonist on phospholipase C (PLC) level was investigated in rat cerebral cortex slice preparations adopting immunohistochemistry approach. Nine Wistar rats PND12 were grouped (n = 3 for each group) as follows: group 1 contained native rats (Control); animals in group 2 and 3 received the SB-334867 vehicle and SB-334867 (10 mg/kg, i.p) daily from PND12 to PND30. The results showed that orexin antagonist decreased PLC levels in layers II, III (P < 0.01), I and V/VI (P < 0.05) of visual cortex. Therefore, it can be concluded that orexin receptor antagonist may decrease the level of PLC in most layers of the visual cortex.
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