Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice

Abstract

Background: Exendin-4 is a similar peptide to GLP-1 and can interfere with various receptors of GLP-1. Bisphenol A (BPA), as an endocrine disruptor chemical, is used in a wide range of plastic products. Objectives: The aim of this study was to clarify several exendin-4 aspects in treatment of metabolic disorders. Methods: In in vivo condition, the BPA (100 g/kg) and exendin-4 (4 nmol/kg/d) were administered for 20 days in four dierent groups, and blood glucose, insulin, lipid profile, adipocyte hormones and oxidative stress markers were examined. Results: The results indicate that co-administration of exendin-4 and BPA modified hyperglycemia and hyperlipidemia induced by BPA. Bisphenol A reduced antioxidant level, whereas exendin-4 improved these eects. Conclusions: The findings of these studies suggest that the use of exendin-4 is useful in hyperglycemia, hyperlipidemia and metabolic disorders, induced by BPA. 1. Background Metabolic disorder is a series of risk factors that cause health complications such as diabetes and cardiovascular disease (1). Nowadays phenolic pollutants such as Bisphe- nol A (BPA) are common endocrine disruptor chemicals (EDCs) that intervene with classic and non-classic recep- tors of estrogen. Inappropriate activation of estrogen re- ceptors is associated with problems such as type II dia- betes and metabolic disorders (2-4). Bisphenol A, as an EDC, is the constituent unit of poly- carbonate and epoxy resins, which are used in a wide range of products such as canned food lining, dental sealants, thermal papers, plastic packs and indoor air (5- 7). The direct release of BPA to the environment occurs at the processing step, through release to the air, soil and ground penetration. According to environmental protec- tion agency of American, the release of BPA to the sur- rounding is more than one million pounds around the globe (8). Thus, it is not surprising that BPA is visible in foods, polluted air, soil, drinking and ground water. Exendin-4 is a 39 amino acid peptide that has 53% se- quence similarity to GLP-1 and can interfere with various receptors of GLP-1, but exendin-4 eects on metabolism