Abstract
Alpha-Synuclein (aSyn) stabilizes small unilamellar vesicles (SUV) by reducing the vesicle's surface tension and membrane rigidity. Using coarse-grained molecular dynamics simulations we explored the membrane remodeling characteristics of aSyn bound to DPPC lipid vesicles. By combining our recently developed Spherical Harmonics fluctuation analysis with 3-dimensional pressure tensor calculations we were able to characterize aSyn's effect on both structure and mechanical properties of DPPC vesicles. Our findings highlight a dramatic reduction in membrane surface tension and increased membrane fluctuations, suggesting a less rigid bilayer, for the aSyn vesicle system relative to pure DPPC.
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