Abstract
The vanilloid receptor – 1 (VR1) is a polymodal (activated by capsaicin, noxious heat, protons) calcium (Ca2+) channel expressed in nociceptive dorsal root ganglion (DRG) neurons. These neurons can be responsible for the pain felt under a variety of conditions like neuropathic pain associated with late stages of cancer, osteoarthritis, rheumatoid arthritis and diabetic neuropathy. Potent antagonist of the VR1 failed as drugs because of important side-effects like uncontrollable fever, showing that non-selective, global inhibition of the VR1 is not possible.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
