Abstract
Ca-dependent neurotransmitter release is commonly seen as the consequence of an allosteric interaction between one or several Ca-sensors and SNARE-mediated exocytosis. So far, this process has been modeled in terms of a simplified allosteric model, in which a cooperative Ca-binding reaction is coupled to an allosteric transition. Here, I explore classical allosteric models, in which Ca binds independently to several binding sites, however with different affinities and kinetics to the ‘relaxed’ and ‘tense’ states, respectively. In particular, I consider cases, in which the binding sites are heterogeneous (e.g. different isoforms of synaptotagmin) and may mix in varying proportions to form a release apparatus. Results are compared to published ‘dose response curves’ from the Calyx of Held.
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