Abstract
This study was to evaluate and investigate the effects of using different drugs on reducing the frequency and severity of Post- ERCP pancreatitis. The study was done on 90 randomized patients with extrahepatic cholestasis and divided into three groups. Post ERCP pancreatitis was diagnosed by laboratory investigations, ultra-sonography and triphasic abdominal CT criteria of pancreatitis. The results of this study showed that there was a statistically significant difference in the percentage of knife precut between the studied groups. There was a statistically significant difference in the degree of post ERCP pancreatitis during comparison the control group with each studied drug group, in which allopurinol has a protective role in the occurrence of post ERCP pancreatitis by regression analysis. It is concluded to use allopurinol before ERCP procedure.
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