Abstract
Stimulation of DNA and RNA synthesis did not occur in mixed macrophage cultures (MMC) consisting of macrophages growing in different allogeneic combinations, compared with syngeneic cultures. Incubation of immune macrophages with either macrophages bearing those alloantigens used for immunization or unrelated alloantigens led to suppression of 3HTdR incorporation. Specific killing, studied by 86Rb uptake, was effected by immune macrophages growing in contact with target macrophages bearing the sensitizing alloantigens. Repeated immunization was found to be important for optimal macrophage cytotoxic capacity. Cell crowding was important for maximum killing effect, and no killing occurred when immune macrophages were separated from the specific allogeneic target cells. Immune spleen cells were capable of arming nonimmune macrophages and rendering them cytotoxic. This suggests that macrophage cytotoxicity may be due to a product(s) derived from lymphocytes and attached to the macrophage surface.
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