Abstract
Autogenous and allogeneic demineralized dentin matrices (Auto-DDM and Allo-DDM, respectively) are currently used for guided bone regeneration (GBR). Buccal marginal bone (BMB) resorption is critical for successful implant integration. This study analyzed BMB resorption around dental implants for GBR between the control group (Auto-DDM graft) and experimental group (Allo-DDM graft). From 2014 to 2019, we enrolled 96 patients (59 males, 37 females, average 57.13 years) who received GBR (52 and 44 using Allo-DDM and Auto-DDM, respectively,) without a barrier membrane and a simultaneous single dental implantation (54 in the maxilla and 42 in the mandible). BMB height was measured immediately after GBR, at prosthetic loading, and 12 months after loading. BMB resorption was classified as initial resorption (between GBR and prosthetic loading) and functional resorption (during 12 months after prosthetic loading). The differences in the BMB levels of Auto-DDM and Allo-DDM were analyzed between the initial and functional resorption stages by independent sample t-test. Auto-DDM and Allo-DDM showed similar BMB changes in initial resorption (0.73 ± 0.97 and 0.72 ± 0.77 mm, respectively) and functional resorption (0.69 ± 0.81 and 0.48 ± 0.58 mm, respectively) without a significant difference between the maxilla and mandible. For GBR, Allo-DDM is comparable to Auto-DDM in terms of BMB resorption.
Highlights
Autogenous demineralized dentin matrix (Auto-DDM) has been widely used in implant dentistry in Korea since 2008 for socket preservation, alveolar ridge augmentation, sinus augmentation, and guided bone regeneration (GBR) associated with dental implants [1,2]
Transforming factors in dentin induce the growth of undifferentiated mesenchymal cells, and these cells are converted into chondroblasts and osteoblasts to form new bones [8]
This study showed that the mineralized whole tooth allograft (WTA)
Summary
Autogenous demineralized dentin matrix (Auto-DDM) has been widely used in implant dentistry in Korea since 2008 for socket preservation, alveolar ridge augmentation, sinus augmentation, and guided bone regeneration (GBR) associated with dental implants [1,2]. Sci. 2020, 10, 4661 factor (FGF), and bone morphogenetic protein (BMP) [4,5]. Fabrication process of DDM removed dental stem cells [6,7], DDM is an “inductive substrate” due to transformation of the fibroblasts of the mesenchymes into cartilage or bone in the extra-skeletal site. Transforming factors in dentin induce the growth of undifferentiated mesenchymal cells, and these cells are converted into chondroblasts and osteoblasts to form new bones [8]. Auto-DDM has shown promising clinical and histological results as an alternative to autogenous bone grafts without the limitations of donor availability, risk of infection at the donor site, and marked resorption rates of ≥50% [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
