Abstract
The importance of skeletal muscles in the development of osteoarthritis (OA) is known. However, in OA, strengthening the muscle is arduous process. This study investigated the effects of muscle enhancement and support therapy (MEST), a novel device for the intramuscular insertion of cog polydioxanone filament intended to hold and stimulate surrounding muscles, on OA-induced symptoms. In our results, the MEST attenuated OA-induced pain and mobility limitations, as evidenced by increases in withdrawal thresholds, rearing duration and travelled distance in an open cage, and fall latency from rotarod. It further restored atrophic rectus femoris muscle (RFM) in OA animals by increasing mass, decreasing nucleus density, and increasing the cross-sectional area of muscle fibers. Decreased collagen and insulin-like growth factor 1 levels in OA animals were restored without affecting the interleukin-6 and tumor necrosis factor-alpha levels in RFM. No evidence of structural improvement in the knee was observed via computed tomography after MEST. These results suggest that MEST in the quadriceps is effective for relieving pain and motor impairment in knee OA animals by restoring atrophic muscles, providing a novel therapeutic strategy for OA symptom management.
Highlights
Osteoarthritis (OA) is the most common joint disease worldwide, with age-associated increases in both incidence and prevalence [1]
We further examined the effects of muscle enhancement and support therapy (MEST) on the local amount of collagen, insulinlike growth factor 1 (IGF-1), and pro-inflammatory cytokines in vitro, as well as the structural changes confirmed via micro-computed tomography in OA knee joints
monosodium iodoacetate (MIA)-injected animals showed mechanical hypersensitivity, which started within a week after the 1st MIA injection, worsened later, and was maintained until day 56 compared to Naïve animals that showed stable paw withdrawal threshold (PWT) throughout the entire experiment (Figure 2A)
Summary
Osteoarthritis (OA) is the most common joint disease worldwide, with age-associated increases in both incidence and prevalence [1]. The PDO led to stressshielding phenomena by unloading the autograft from tensional stimulation of fibroblasts in the tissue [18] Paying attention to these points, in this study, we tried to confirm the improvement effect of OA symptoms using PDO filaments in OA-induced joint pain in terms of physical activity reduction and muscle weakness. For this purpose, flexible filaments equipped with special cogs were used. Cog PDO filaments may effectively hold and support surrounding muscles to increase joint stability and relieve pain. Our study shows that MEST-induced skeletal muscle changes may help alleviate the symptoms of OA
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