Alleviation of Diabetic Dyslipidemia in Alloxan-Induced Diabetic Rats using Aqueous Seed Extract of Persea Americana

Abstract

Diabetes Mellitus is accompanied by hypercholesterolemia, hyperlipidemia, and hepatic steatosis apart from hyperglycemia. Alleviation of diabetic dyslipidemia in alloxan-induced diabetic rats using aqueous seed extract of Persea americana on induced Albino rats. A total of thirty Albino rats were divided into six groups of 5 rats: Group A: normal control, Group B: Negative control, Group C: Positive control 1, Group D: positive control 2, Group E: Test group 1, Group F: Test group 2. The intoxication of albino rats with alloxan monohydrate produced low high-density lipoprotein (HDL), increased triglycerides (TG), total cholesterol (TC) and low-density lipoprotein (LDL) after hyperglycemia. Results obtained from the diabetic study showed that plant extracts decreased blood glucose in a dose-dependent fashion. The decrease was significant when compared to positive control 1. Similarly, treatment with the seed extracts normalized the lipoprotein abnormalities in a dose-dependent manner. The positive control 2 using atorvastatin was effective in TG and TC reduction while the High dose aqueous seed extract of Peresa americana was effective in the normalization of LDL and HDL. Phytochemical composition of the aqueous seed extract gave reactions for alkaloids, flavonoids, tannins, saponins, phenols, steroids, and cyanogenic glycosides. The findings may support the acclaimed traditional use of Persea americana seed in controlling hyperglycemia in diabetes and its complications.