Abstract
U.S. syphilis rates and vertical transmission have been increasing since 2001. The only treatment for syphilis in pregnancy is penicillin G (PCN). For those with a PCN allergy, no alternate antibiotics are effective, and they are recommended to be evaluated, desensitized if needed, and treated with PCN. Patients can either undergo allergy evaluation and risk stratification, or be directly desensitized at obstetric point of care. In this study, we evaluated allergy evaluation for PCN-allergic, syphilis-positive pregnant individuals as a means to prevent potential anaphylaxis with PCN exposure.
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