Abstract
Alkyl amines, C11–14‐branched, monohexyl and dihexyl phosphates The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated alkyl amines, C11‐14‐branched, monohexyl and dihexyl phosphates to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. In a screening study according to OECD Test Guideline 422, inflammation in the lymph nodes and the adrenals was seen at the lowest dose of 10 mg/kg body weight and day after gavage administration to rats. The mixture is irritating to skin and eyes but an inhalation study to address possible irritation potential in the respiratory tract is lacking. For this reason and as no systemic NOAEL was obtained, a MAK value could not be derived and the substance is assigned to Section II b of the List of MAK and BAT Values. In the screening study, no adverse effects on fertility of the parental animals or on development of the progeny were observed up to the highest dose of 100 mg/kg body weight and day. The substance is not genotoxic in vitro and studies in vivo as well as carcinogenicity studies are not available. There are no clinical results on contact sensitization in humans and no unequivocally positive sensitization tests in animals. The amount of skin absorption was not investigated and could not be calculated.
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