Abstract
Interest in the possible central nervous system regulation of aldosterone secretion has been centered on a region including the pineal gland, the subcommissural organ and the superior colliculi. These parts of the nervous system adjoin the pretectal area and lesions of this area in humans are characterized by unique oculomotor abnormalities. We have studied basal urinary aldosterone levels and their response to sodium restriction in 7 patients with such lesions. Six subjects with focal central nervous system disease not involving the pretectal area served as controls and were similarly studied. All the control subjects showed the expected rise in urinary aldosterone following sodium restriction. In 4 of the 7 patients with pretectal disease such a rise failed to occur.
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