Abstract
BackgroundThe therapeutic potentials of the methanolic extract of pineapple peel against alcohol – induced lung injury in male albino rats was investigated. GC – MS was used in characterizing secondary metabolites of the extracts.MethodsOxidative stress was induced by oral administration of ethanol (20 % w/v) at a dosage of 5 mL/kg body weight in rats. After 28 days of treatment, the rats were fasted overnight and sacrificed by cervical dislocation. Lung tissue homogenates were used for the assessment of protein concentration, reduced glutathione (GSH), catalase, superoxide dismutase (SOD) and lipid peroxidation.ResultsGCMS analysis revealed the presence of 10 compounds with ethanimidic acid, ethyl ester (32.52 %) being the most predominant compound. Ingestion of alcohol led to a significant (p < 0.05) reduction in GSH, malondialdehyde (MDA) and protein levels in the lung tissues, this was significantly reversed on treatment with the extract. Ingestion also led to increased significant (p < 0.05) SOD and catalase activity respectively. This was significantly (p < 0.05) reduced on treatment with the extract.ConclusionThese results insinuate the therapeutic potential of the extract against alcoholic oxidative damages in lungs. The identified compounds may influence free radical scavenging and arrest of lipid peroxidation, thereby restoring redox homeostasis.
Highlights
The therapeutic potentials of the methanolic extract of pineapple peel against alcohol – induced lung injury in male albino rats was investigated
H2O2 produced during alcohol metabolism to acetaldehyde by cytochrome P450-2E1 (CYP2E1) in both liver and lungs interacts with copper/iron leading to generation of Reactive Oxygen Species (ROS) and/or its products [4, 5]
This paper aims at investigating the therapeutic potentials of the methanolic extract of pineapple peel against alcohol – induced lung injury in male albino rats as well as characterize its secondary metabolites using Gas Chromatography Mass Spectrometer (GC – MS)
Summary
The therapeutic potentials of the methanolic extract of pineapple peel against alcohol – induced lung injury in male albino rats was investigated. The medicinal properties of plants especially its antioxidant role against most ROS induced injuries are well documented [6, 7]. These properties have been attributed to their phytochemical constituents with much emphasis on flavones, isoflavones, flavonoids, anthocyanin, coumarin lignans, catechins and isocatechins owing to their well studied antioxidant activities [6]. Pineapple (Ananas cosmosus) peels have been an important ingredient in ethno medicine. They have been used traditionally in the treatment and management of various ailments.
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