Abstract
THE notion of the hereditability of alcoholism has alternated between acceptance and rejection1–4. Convincing evidence for a genetic involvement in man has been reported5,6, but the issue remains controversial7. Because nature and nurture are so intertwined, and the methodology of their separation in humans is difficult, and even often suspect, inbred mouse strains have been used to examine the genetic basis of the disparate voluntary alcohol intakes seen in these strains8,9.
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