Abstract
Objective: In this study, we aimed to investigate plasma homocysteine (Hcy) changes in patients within the acute period of ischemic stroke. Material and Methods: In this cross-sectional study, a total of 110 patients with acute ischemic stroke presenting within 48 hours of onset and 45 age and gender-matched healthy subjects were evaluated. Hcy was measured on 2nd, 4th, 7th, 10th and 14th days of the hospitalization. Control samples were also collected after a 12-hour fasting period. Results: Statistically significantly lower Hcy levels were found in acute ischemic stroke patients on the 2nd day compared to the control group (p<0.001). No significant difference was found in the 4th day between the groups (p=0.478). In all other days on which test was performed, Hcy levels were statistically significantly higher in acute ischemic stroke group compared to the control group (p<0.001 for all). Conclusion: This study suggests that Hcy levels are not significantly elevated after recent ischemic stroke, but rise in the 2nd week of admission, and our findings do not support the hypothesis that raised plasma Hcy levels predate ischemic stroke. Therefore, increased plasma Hcy level is a consequence of disease process, and has no value as a predictor of ischemic stroke.
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