Abstract
Free radicals are one of the cause of various diseases. The use of synthetic antioxidant compounds could prevent the effect of the free radicals, however may cause adverse effects on the human body such as impaired liver, lung, intestinal and poisoning. Therefore antioxidant from natural resources needs to be developed. The purpose of this research was to determine the antioxidant activity and IC50 value of the ethanol extract of ganitri (Elaeocarpus ganitrus Roxbs.) leaves. Ganitri leaf ethanol extract activity test was carried out using DPPH method with vitamin C as a standard. Antioxidant activity was determined as a decreas in the absorbance of DPPH at 517 nm wavelength after an addition of the extract with the concentrations of 20, 40, 80, and 100 ppm. The antioxidant acitivity measurement of the ganitri leaf extract showed that the linier regression equation obtained was y = 0.3669x + 29.546, r = 0.4573 while the IC50 value was 54,12 ppm. Based on the result, it is concluded that the ethanol extract of ganitri (Elaeocarpus ganitrus Roxb.) leaf showed was categorized as strong antioxidant.
Highlights
Free radicals are one of the cause of various diseases
The use of synthetic antioxidant compounds could prevent the effect of the free radicals
Ganitri leaf ethanol extract activity test was carried out using DPPH method with vitamin C
Summary
Naelaz Zukhruf Wakhidatul Kiromah*, Sadam Husein, Titi Pudji Rahayu Program Studi Farmasi Program Sarjana, Sekolah Tinggi Ilmu Kesehatan Muhammadiyah Gombong, Jl.Yos. Penggunaan senyawa antioksidan sintetis dapat mencegah radikal bebas namun menyebabkan efek buruk pada tubuh manusia seperti gangguan fungsi hati, paru-paru, usus, dan keracunan sehingga perlu dikembangkan antioksidan dari bahan alam. Tujuan penelitian ini adalah mengetahui aktivitas antioksidan ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.). Uji aktivitas antioksidan ekstrak etanol daun ganitri dilakukan menggunakan metode DPPH dengan pembanding vitamin C. Kemampuan antioksidan diukur berdasarkan penurunan absorbansi DPPH pada panjang gelombang 517 nm setelah penambahan ekstrak dengan konsentrasi 20, 40 ,80 dan 100 ppm. Hasil uji aktivitas antioksidan ekstrak etanol daun ganitri didapatkan persamaan regresi linier y = 0.3779x + 29.546 dengan nilai r= 0.4573 dan diperoleh nilai IC50 sebesar 54,12 ppm. Ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb) memiliki aktivitas antioksidan dengan kategori kuat.
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