Abstract
Carbachol, noradrenaline, and serotonin stimulated the accumulation of inositol phosphates in a dose-dependent manner and maximally by 172.4%, 71.2%, and 51.6%, respectively, in 3-day-old rabbit retinal cultures. In contrast, dopamine, nicotine, isoproterenol, clonidine, 8-OH-dipropylaminotetralin, and gamma-aminobutyric acid were ineffective. In older cultures identified as containing primarily Müller cells, only carbachol and noradrenaline were able to induce a significant stimulatory response. The carbachol-, noradrenaline-, and serotonin-induced responses were pharmacologically characterized and shown to be mediated by muscarinic, alpha 1-adrenergic, and 5-hydroxytryptamine2 receptors, respectively. The results of the present study show that primary retinal cultures of 3 days of age give results comparable with those of the intact retina. Furthermore, it is demonstrated for the first time that putative Müller cells in cultures possess functional muscarinic and alpha 1-adrenergic receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
