Abstract
The objective of this present work is to optimize and prepare silver nanoparticles(AgNPs) in Dioctyl sodium sulfosuccinate (AOT) microemulsion (ME) for oral use and to investigate its antibacterial and anticancer activity in vitro and in vivo. In vitro drug release study confirmed that faster release of drug at the tumor cells compared to the blood circulation. It also showed a potential antibacterial activity against pathogenic bacteria. The optimized AgNPs loaded ME confirmed significant cytotoxicity against MCF-7 cancer cell line with IC50 16.72 ± 0.014 μg/mL and significant reduction in solid Ehrlich tumor growth in compared to the control, placebo and pure drug.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Polymeric Materials and Polymeric Biomaterials
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.