Abstract
The kinetics of the sodium dependence of high affinity glutamic acid transport has been studied in synaptosomes from two and thirty month old rats. The data were fitted to kinetic models, and the minimal model giving best fit was identified for each age group. This minimal best fit model was found to be identical for both young and aged animals. Although there had occurred no basic change with age in the mechanism by which carrier, sodium, and glutamate interact in the transport process, substantial quantitative changes were found to occur; these changes result in a reduced transport capacity in the aged animals. The rate equation for the best fit model was utilized to define and calculate certain parameters which were then used to quantitatively compare the transport mechanism in young and aged animals.
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