Abstract
Aggressive angiomyxoma (AAM) is a rare myxoid mesenchymal tumor that occurs almost exclusively in the adult pelvic-perineal region and predominantly in females. Only 1 case of AAM occurring outside this region has been reported. Here we report another such case. The patient was referred for evaluation of a firm nonmovable mass of the supraclavicular fossa that had progressively enlarged within the previous year. MRI showed an infiltrative growth pattern with adhesion to adjacent anatomic structures. Wide excision was attempted, but a clear margin could not be achieved. The histopathology revealed characteristic features of AAM, including stellate to spindle-shaped tumor cells set in a myxoid background, with hyalinizing thick-walled vessels and characteristic immunophenotype. Accurate diagnosis and a definite surgical margin are crucial because AAM is locally aggressive and easily recurrent. Our case deserves attention because it shows that AAM may exist in the head and neck.
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