Abstract
BackgroundCisplatin (CP) is one of the effective anticancer drugs, but it causes many side effects. Aged garlic extract (AGE) is a natural herbal product used in management of many diseases.ObjectiveThis study aimed to investigate effect of AGE on CP-induced nephrotoxicity in rats.Material and methodsFour equal groups of adult male rats: control, AGE -treated (250 mg/kg, once oral dose/ 21days), CP-treated (7.5 mg/kg once i.p. on day 16th.), combined AGE and CP-treated were used. Body and kidneys weights of each rat were calculated. Serum levels of kidney biomarkers were assessed. Malondialdehyde (MDA) and reduce glutathione (GSH) levels, superoxide dismutase (SOD) and catalase (CAT) activities of renal tissues were measured as well. Renal samples from each rat were prepared for light and electron microscopic examinations.ResultsHemorrhage, glomerular atrophy, inflammatory cell infiltration, tubular necrosis and degeneration were observed in CP-treated rats. Also, a significant (P<0.001) reduction in SOD & CAT activities, GSH levels accompanied with a significant increase in serum levels of kidney biomarkers and MDA were determined in CP-treated rats compared to control group. However, most of CP-induced histomorphological, ultrastructural and biochemical changes were improved in animals pretreated with AGE.ConclusionSuch renoprotective effect of AGE may be attributed to its antioxidant activity.
Highlights
Cisplatin (CP) is an inorganic, divalent, water soluble, platinum-containing compound
A significant (P
The final body weight of the rats showed a significant (P < 0.05) reduction in CP-treated rats compared to both control and Aged garlic extract (AGE)-treated animals
Summary
Cisplatin (CP) is an inorganic, divalent, water soluble, platinum-containing compound. Its clinical use is associated with dose and duration-dependent nephrotoxic side effect [3]. Medicinal plants and natural herbal products have potential antioxidant activity and are often administered along with chemotherapeutic agents to provide better protection against their toxic side effects [4,8,9]. To increase the clinical usefulness of CP, various free radical scavengers have been used to ameliorate CP-induced nephrotoxicity [3,8]. Much attention has been given to possible role of natural dietary antioxidants in protecting the kidney against CP-induced nephrotoxicity [8,9,10,11]. Cisplatin (CP) is one of the effective anticancer drugs, but it causes many side effects. Aged garlic extract (AGE) is a natural herbal product used in management of many diseases
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
