Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women.

Abstract

Background:Ovarian reserve declines with age. However, there are considerable ethnic differences in the decline of ovarian reserve between individuals.Aim:This study aimed to make age-specific percentile charts of anti-Mullerian hormone (AMH) and antral follicle count (AFC) in Indian infertile women and to find the proportion of young women with low ovarian reserve.Setting and Design:This was a retrospective data analysis of AMH and AFC of 5525 infertile women from August 2015 to December 2018.Materials and Methods:Infertile women aged 20– 44 years, with body mass index 18–32 kg/m2 and having both ovaries were included in the study. Women with pituitary/adrenal disorders, malignancy, total AFC >40, tuberculosis, endometriosis, autoimmune disorders, smoking, chemotherapy, radiotherapy and recent ovarian surgery were excluded from the study.Statistical Analysis:Comparison between groups was done by Chi-square test.Results:About 14.5% of women <35 years and 50.5% of women >35 years had low AMH values (<1.1 ng/ml). In addition, 5.6% of women <35 years and 23.6% of women >35 years had a low AFC of ≤5. In this study, 55.7% of women who had low AMH and 50.7% who had low AFC were <35 years of age. The median AMH values were 4.23 ng/mL in 20–25 years’ age group, 3.48 ng/mL in women aged 26–30 years, 2.43 ng/mL in women aged 31–35 years, 1.28 ng/mL in women aged 36–40 years and0.52 ng/mL in 40–44 years’ age group. The median AFCs were 20, 18, 14, 10 and 6 for each of the age groups, respectively.Conclusion:This study suggests that approximately more than half of the infertile women who were tested to have low ovarian reserve were <35 years of age.