Abstract
Plasma triglyceride (TG) concentrations rise with age, and we have carried out studies of very low density lipoprotein (VLDL) kinetics in the rat in an effort to define the cause of this phenomenon. Efficiency of VLDL-TG secretion by perfused rat liver decreases as rats age from 1 1 2 –12 mo . However, this is compensated for by an increase in liver weight, and VLDL-TG secretion per perfused liver does not change with age. In contrast, total VLDL-TG secretion by the intact rat increases significantly as rats grow from 1 1 2 –12 mo of age, and this increase is proportionate to the age-related increase in liver weight. The ability of the older rat to maintain VLDL-TG secretion proportionate to liver weight is most likely due to the concomitant rise in plasma free fatty acid concentration that occurs with age. However, the efficiency with which VLDL-TG is removed from plasma is not maintained as rats age. Consequently, the age-related rise in plasma TG concentration is due to an increase in VLDL-TG secretion proportionate to secretory mass, accompanied by a relative decline in efficiency of VLDL-TG removal from plasma.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
