Age-related changes in plasma porcine growth hormone (GH) profiles and insulin-like growth factor-I (IGF-I) concentrations in Large White and Meishan pigs

Abstract

Plasma GH profiles and IGF-I concentrations were determined in Large White intact male (LW-M), female (LW-F) and castrated male (LW-C) and in Meishan intact male (MS-M) pigs between 10 and 140 d of age. Mean GH levels slightly increased between 10 and 45 d of age in LW pigs, in connection with an alteration in the temporal distribution of GH peaks, whereas neither interpulse GH level nor maximum GH level were affected. Mean GH levels decreased after 45 d of age, in connection with a decline in maximum and interpulse GH levels. IGF-I concentrations were low between 10 and 45 d of age and increased thereafter. GH secretory profiles did not differ significantly between LW-M and LW-F at either age. Castration had no effect at 45 d of age whereas LW-C exhibited lower mean, maximum and interpulse GH levels and smaller sum of GH pulse areas and widths than LW-M or LW-F at 140 d of age. IGF-I was lower in LW-C or LW-F than in LW-M at 140 d of age. The pattern of age-related changes in GH and IGF-I was similar in MS and LW pigs. However, interpulse GH level was higher and sum of GH pulse widths was smaller in MS-M than in LW-M, whatever the age. The results indicate that: i), GH and IGF-I secretions were similar in Meishan, and Large White pigs; ii), in both breeds, GH secretion declined after 45 d of age, due to decreased maximum and interpulse GH levels; iii), sex and/or castration effects on GH and IGF-I secretion were observed after 45 d of age only.