Abstract
ABSTRACTHow drug concentration in skin and lung due to vascular action changed with aging was examined quantitatively by a bioassay using bacteria. The concentration of the drug (anticancerous agent, Bleomycin) did not decrease in the skin of older mice as compared with that in younger mice, but showed a decrease in the lungs.An experiment using Kallikrein, a peripheral vasodilator, revealed that the kinin‐kallikrein system exists in mice.The peripheral circulation increasing action of Kallikrein decreased in the skin and increased in the lungs of older mice as compared with young mice.
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