Abstract
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. An increase in MS incidence over time is reported in several regions of the world. We aimed to describe the evolution of the annual MS incidence in the Lorraine region, France, from 1996 to 2015 and to analyze potential components of a possible change by a temporal effect of age at MS onset, MS onset period, and birth cohort, overall and for each sex. Cases were identified from ReLSEP, a population-based registry of MS cases living in Lorraine, northeastern France, with MS onset between 1996 and 2015. Age-period-cohort modeling was used to describe trends in MS incidence. Annual age- and sex-standardized incidences were relatively stable: 6.76/100 000 population (95%CI [5.76–7.91]) in 1996 and 6.78/100 000 (95%CI [5.72–7.97]) in 2015. The incidence ratio between women and men was 2.4. For all time periods, the peak incidence occurred between ages 25 and 35 years. Age-period–adjusted cohort and age-cohort–adjusted period analyses did not reveal a period or cohort effect. The incidence of MS remained stable over the study period in Lorraine, and we could not identify any particular effect of disease onset period or birth period on this evolution.
Highlights
The epidemiology of multiple sclerosis (MS) has changed since the middle of the twentieth century regarding temporal, geographical and demographic alterations in the patterns of disease, mortality rates and causes ofdeath[1]
This study aimed to describe the evolution of the annual incidence of Multiple sclerosis (MS) in the Lorraine region over the
The present study was conducted on incidence data collected from the population-based ReLSEP registry in Lorraine, France, over a period of 20 years (1996–2015)
Summary
The epidemiology of multiple sclerosis (MS) has changed since the middle of the twentieth century regarding temporal, geographical and demographic alterations in the patterns of disease, mortality rates and causes ofdeath[1]. The epidemiology of multiple sclerosis (MS) has changed since the middle of the twentieth century regarding temporal, geographical and demographic alterations in the patterns of disease, mortality rates and causes of. According to the Atlas of MS (2020), this neurodegenerative disease of the central nervous system reached a worldwide prevalence of 2.8 million in 20202. MS is the most common non-traumatic disabling disease with an irreversible character and affects young adults, in particular women[3,4,5]. A combination of environmental and genetic factors could be triggering f actors[6,7], and they affect the evolution of the risk of MS. The global prevalence and incidence of MS is increasing in many c ountries[8,9,10]. MS represents a social burden in countries where its incidence is h
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
