Age is an independent risk factor for increased morbidity in elective colorectal cancer surgery despite an ERAS protocol.

Abstract

Elderly patients with colorectal cancer are high-risk surgical candidates. ERAS protocols have been developed to mitigate against these risks. We performed this study to quantify the risks which elderly patients face and then to determine independent risk factors for short-term ERAS-specific outcomes. An analysis of a prospectively collected audit database of all patients who underwent elective colorectal cancer resection within an ERAS framework from January 2018 to December 2018 was performed. Elderly was defined in our study as age ≥ 65years. There were 172 elective colorectal cancer resections performed. Ninety-seven (56.4%) were elderly. Elderly patients were at increased risk of developing post-operative complications (33.0% vs 16.0%, p= 0.011), longer time to diet (3.4 vs 2.2days, p= 0.001), and longer hospital stay (10.9 vs 6.7days, p= 0.007). Independent risk factors were determined for the abovementioned three outcomes. Elderly status was the only risk factor for increased complications (OR 2.61 95% CI (1.05-6.51), p= 0.040). For delayed time to soft diet, male gender (OR 6.67(1.92-20.0), p= 0.002), open approach (OR 9.06(2.26-36.30), p= 0.002), and increased operative time (OR 1.01(1.00-1.01) p= 0.014) were risk factors. Finally, elderly age (OR 5.53(1.82-16.84), p= 0.003), leucocyte count (OR 1.39(0.76-2.57), p= 0.038), open approach (OR 5.26(1.41-19.62), p= 0.013), operative time (OR 1.01(1.00-1.01), p= 0.021), and Clavien-Dindo classification (OR 7.97(1.27-49.88), p= 0.027) were risk factors for prolonged length of stay. Elderly patients are intrinsically at risk for increased complications, longer time to soft diet and longer hospital stay. ERAS protocols may need to be specifically tailored for elderly patients.