Abstract
BackgroundIn dogs, occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years. Hyperlipidemia has been regarded as a common characteristic for obese animals and hyperlipidemic condition may be associated with inflammation, oxidative stress and lipid composition changes. In this study, we investigated the changes in plasma cholesterol and triglyceride (TG) profiles and metabolite concentrations in 24 dogs (young group: 0-7 years old, n = 12, aged group: 8-13 years old, n = 12).ResultsPlasma adiponectin (ADN) concentrations were significantly lower in aged dogs than those in young dogs (mean ± SD, 17.2 ± 10.0 μg mL-1 vs 29.3 ± 12.5 μg mL-1, respectively; P <0.05). Although there were no significant differences statistically, aged dogs showed significantly higher plasma alpha1- acid glycoprotein (alpah1-AG) levels compared to those in young dogs. Plasma cholesterol lipoprotein and TG lipoprotein were divided into four fractions by biphasic agarose gel electrophoresis technique. The levels of the third TG-lipoprotein fraction from the positive pole (TG Fraction 3) were significantly higher in aged dogs than in young dogs (mean ± SD, 143.0 ± 109.3 mg dL-1 vs 55.2 ± 31.3 mg dL-1, respectively; P <0.05). On the correlation coefficient analysis by Peason’s method, moderate positive correlations were seen between the age and TG (r = 0.446, P = 0.029), TG Fraction 3 (r = 0.516, P = 0.010), malondialdehyde (r = 0.146, P = 0.043), alpha-1 AG (r = 0.448, P = 0.028) levels, respectively. Moderate negative correlations were seen the age and total cholesterol (TC) Fraction 2 (r = -0.446, P = 0.029), glucose (r = -0.637, P = 0.001), ADN (r = -0.408, P = 0.048), respectively.ConclusionsPresent data suggest biochemical characteristics of lipid metabolism disorder may be affected by aging in dogs.
Highlights
In dogs, occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years
Hyperlipidemia has been regarded as a common characteristic for obese dogs [1], and prevalence of overweight and obese dog has been estimated as 24% to 30% [2]
Plasma malondialdehyde (MDA) concentrations have been regarded as a lipid peroxide stress marker [7], and the correlation between plasma lipid peroxide levels and high prevalence of diabetic patients has been reported in human [8,9]
Summary
Occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years. Hyperlipidemia has been regarded as a common characteristic for obese animals and hyperlipidemic condition may be associated with inflammation, oxidative stress and lipid composition changes. We investigated the changes in plasma cholesterol and triglyceride (TG) profiles and metabolite concentrations in 24 dogs (young group: 0-7 years old, n = 12, aged group: 8-13 years old, n = 12). Hyperlipidemic condition could be a deteriorative factor for metabolic syndrome in dogs [3] Physiological variables, such as age, body weight and sex may affect hyperlipidemia severity in dogs [4]. We investigated the changes in above mentioned plasma parameters and cholesterol and TG profiles in 24 dogs with different ages though we could not elucidate the daily rhythmicity of lipid levels completely [10]
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