Abstract
Aged rhesus monkeys trained for 3 months on a delayed-response task are impaired relative to young, adult monkeys similarly trained. The delayed-response performance of eight aged (18 + years) and five young (5–8 years) adult monkeys after extensive training (> 1 yr) on the task was examined. Recall of the spatial position of a visual stimulus was measured following retention intervals of various durations using a delay titration method. It was found that increased experience on the task improved performance in both age groups. However, aged monkeys remained reliably and significantly impaired under conditions requiring short-term memory. These findings further confirm the utility of nonhuman primate models of age-related cognitive deficits in humans.
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