Abstract
Erythrocyte microrheology changes were measured by cation-osmotic hemolysis (COH) in rats of different age groups (3, 12 and 24 months). COH in 12-month-old rats was significantly lower in low ionic strength media (spectrin skeleton) in comparison with 3-month-old rats. This decrease was much more pronounced in 24-month-old animals, in which a significant decrease in COH in incubating media with higher ionic strength was also observed. The relationship between COH and eryhtrocyte deformability is also discussed. We suggest that changes in biophysical state of spectrin skeleton are followed by changes in lipid bilayer properties.
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