Abstract
An aneurysm is an outward bulge on an arterial wall. Aneurysms are becoming a serious public health concern as the worldwide population ages. Unfortunately, no effective drugs have been developed for aneurysms to date. In addition, aneurysms may be associated with grave prognosis due to conditions such as ruptures and recurrence. Altogether, these factors make earlier aneurysm prevention, diagnosis and intervention strategies even more important. A bioinformatics resource for aneurysm-associated molecules would be helpful for addressing the above issues; however, such a tool is not yet available. In this study, we developed Aneurysm Gene Database (AGD) for the above purpose. AGD contains 1472 aneurysm-gene associations, including 29 types of aneurysms, 967 protein-coding genes, 29 miRNAs, 6 lncRNAs and several other types of molecules. Users can search, browse and download content in AGD. We believe that AGD is a valuable resource that can help us better understand aneurysms and discover novel treatment targets.
Highlights
An aneurysm is defined as an outward bulge on an arterial wall and is associated with significant morbidity and mortality [1, 2]
Since aneurysms may occur anywhere along the full length of the aorta [3], they can be classified into several types based on their location, such as thoracic aortic aneurysm, abdominal aortic aneurysm (AAA) and carotid aneurysm
We obtained the primary result by taking the intersection of the above results, which included the PubMed Identifier (PMID), abstracts, Tax IDs and Gene IDs of 1528 articles containing ‘aneurysm’ that were focused on genes
Summary
An aneurysm is defined as an outward bulge on an arterial wall and is associated with significant morbidity and mortality [1, 2]. Previous studies have shown that the prevalence of AAA is 4–8% among men >65 years. For people aged >45 years, the out-of-hospital death rate reaches up to 80% for AAA rupture. Aneurysm rupture is significantly lethal, and while acute mortality is lower, it still reaches 50% even when patients undergo surgery [13,14,15]
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