Abstract
A mycelial culture of the Kenyan basidiomycete Fomitiporia aethiopica was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes 1–5, for which we propose the trivial name aethiopinolones A–E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities.
Highlights
The fungal kingdom includes many species that produce various classes of structurally unique and biologically active metabolites [1,2]
The mycelial culture showed an interesting secondary metabolite profile when studied by HPLC-MS
Scale-up of fermentation and subsequent preparative chromatography yielded five new triterpenes 1–5, for which we propose the trivial names aethiopinolones A–E
Summary
The fungal kingdom includes many species that produce various classes of structurally unique and biologically active metabolites [1,2]. During the course of our studies on Kenya’s tropical basidiomycetes we have encountered various interesting organisms that yielded new biologically active metabolites such as laetiporins, calocerins, 9-oxostrobilurins and laxitextines [3,4,5]. Another specimen collected in Kenya was identified as Fomitiporia aethiopica, a species that had been first reported from the Ethiopian highlands [6]. The mycelial culture showed an interesting secondary metabolite profile when studied by HPLC-MS. The present paper is dedicated to the first investigation of the secondary metabolite production in mycelial cultures of Fomitiporia aethiopica
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