Abstract
Recent studies have focused on the development of total-body PET scanning in a variety of fields such as clinical oncology, cardiology, personalized medicine, drug development and toxicology, and inflammatory/infectious disease. Given its ultrahigh detection sensitivity, enhanced temporal resolution, and long scan range (1940 mm), total-body PET scanning can not only image faster than traditional techniques with less administered radioactivity but also perform total-body dynamic acquisition at a longer delayed time point. These unique characteristics create several opportunities to improve image quality and can provide a deeper understanding regarding disease detection, diagnosis, staging/restaging, response to treatment, and prognostication. By reviewing the advantages of total-body PET scanning and discussing the potential clinical applications for this innovative technology, we can address specific issues encountered in routine clinical practice and ultimately improve patient care.
Highlights
Over the past few decades, researchers around the world have been intent on improving the sensitivity and resolution of positron emission tomography (PET) imaging
Other authors have identified a promising niche for total-body PET/computed tomography (CT) imaging in drug development
Traditional medicine has been rapidly shifting to the concept of personalized medicine, including molecular targeted therapy, immunotherapy, and theranostics. These personalized medicine techniques have been highly successful in the field of clinical oncology, where clinicians can evaluate specific tumor markers and select patients who might benefit from a specific molecular-targeted therapy, maximizing the therapeutic effect and minimizing toxicity [40]
Summary
Over the past few decades, researchers around the world have been intent on improving the sensitivity and resolution of positron emission tomography (PET) imaging. Recent modifications include the introduction of novel gating methods, iterative reconstruction algorithms, detectors with optimized geometry, time-of-flight technologies, and integration of computed tomography (CT) imaging While these changes have remarkably improved PET quality, the limited axial coverage of current PET scanners continues to be a significant constraint in the face of current imaging systems. By increasing the number of detectors, most emitted photons can be captured, dramatically increasing sensitivity, and allowing for simultaneous dynamic acquisition from all tissues of interest This ultrasensitive high-performance device offers many advantages over conventional systems, such as an enhanced signal-to-noise ratio (SNR), image quality with a shorter acquisition time, and lesser injected radioactivity. Adults requiring longitudinal studies may be able to undergo repeated scans
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