Abstract
Neuroglial cells have a high level of plasticity, and many types of these cells are present in the nervous system. Neuroglial cells provide diverse therapeutic targets for neurological diseases and injury repair. Cell reprogramming technology provides an efficient pathway for cell transformation during neural regeneration, while transcription factor-mediated reprogramming can facilitate the understanding of how neuroglial cells mature into functional neurons and promote neurological function recovery.
Highlights
Neuroglial cells are non-neuronal cells and have received great attention because glial cells have been regarded as important modulators of many aspects of brain function and disease [1]
Neuroglial cells have a high level of plasticity, and many types of these cells are present in the nervous system
Cell reprogramming technology provides an efficient pathway for cell transformation during neural regeneration, while transcription factor-mediated reprogramming can facilitate the understanding of how neuroglial cells mature into functional neurons and promote neurological function recovery
Summary
Neuroglial cells are non-neuronal cells and have received great attention because glial cells have been regarded as important modulators of many aspects of brain function and disease [1]. The term “neuroglia” was originally proposed by Virchow in 1850, who assumed that neuroglia were a class of cells that consisted of neurons embedded in a layer of connective tissue, referred to as “glia”. Glial cells in the CNS consist of astrocytes, oligodendrocytes and microglia, while glial cells in the peripheral nervous system (PNS) consist of Schwann cells (SCs) and satellite
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