Abstract
<span lang="EN-US">Morphine is an opioid drug. Long-term use can cause morphine dependence or addiction, and there are cognitive dysfunction such as abnormal mental behavior, decline in learning and memory, and decline in executive ability. The occurrence of this disease is related to many factors, such as oxidative stress, hippocampal neuronal injury, mitochondrial function injury, etc. Tau protein is a microtubule-associated protein involved in nervous system development. Studies have found that hyperphosphorylation of tau proteins can cause apoptosis of hippocampal neurons<sup>[1]</sup>, and tau proteins can cause oxidative stress<sup>[2]</sup>. Therefore, tau proteins play an important role in the pathogenesis of cognitive disorders. The relationship between morphine dependence and cognitive dysfunction is now reviewed.</span>
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