Abstract
Breast cancer is a highly complicated disease. Advancement in the treatment and prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and progression. Rodent models of breast cancer have developed into premier tools for investigating the mechanisms and genetic pathways in breast cancer progression and metastasis and for developing and evaluating clinical therapeutics. Every rodent model has advantages and disadvantages, and the selection of appropriate rodent models with which to investigate breast cancer is a key decision in research. Design of a suitable rodent model for a specific research purpose is based on the integration of the advantages and disadvantages of different models. Our purpose in writing this review is to elaborate on various rodent models for breast cancer formation, progression, and therapeutic testing.
Highlights
Breast cancer is the most commonly diagnosed cancer and one of the most common cause of cancer death in women worldwide
Every mouse model has advantages and disadvantages, and it is highly important to design a suitable mouse model for each research purpose based on integration of the advantages and disadvantages of different models, and compound techniques of mouse models have more practical application
The rodent models may help to improve the knowledge of breast carcinogenesis mechanism and genetic pathways, as well as creating therapy for modeling clinical breast cancer subtypes and develop innovative cancer therapy
Summary
Breast cancer is the most commonly diagnosed cancer and one of the most common cause of cancer death in women worldwide. Advancement in treatment and prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and progression. Rodent models of breast cancer have developed into premier tools for breast cancer research, and they have generated important insights into the mechanisms that underpin development of the disease and interventional therapies. This review summarizes various rodent models for breast cancer formation, progression, and therapeutic testing
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