Abstract
In the past 20 years, molecular genetic technology has developed rapidly. The leap forward development of single-cell genetic diagnosis technologies represented by whole genome amplification combined with microarray technology or next-generation sequencing not only increased the accuracy of preimplantation genetic diagnosis (PGD) but also greatly expanded the variety and scope of detectable diseases. This paper systematically reviews the clinical application of PGD as well as recent progress of related technologies. Key words: Preimplantation genetic diagnosis; Microarray technology; Next-generation sequencing
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