Biotechnology Advances | VOL. 60

Advances in plant-derived C-glycosides: Phytochemistry, bioactivities, and biotechnological production

Publication Date Nov 1, 2022


C-glycosides represent a large group of natural products with a C-C bond between the aglycone and the sugar moiety. They exhibit great structural diversity, wide natural distribution, and significant biological activities. By the end of 2021, at least 754 C-glycosides and their derivatives have been isolated and characterized from plants. Thus far, 66 functional C-glycosyltransferases (CGTs) have been discovered from plants, and provide green and efficient approaches to synthesize C-glycosides. Herein, advances in plant-derived C-glycosides are comprehensively summarized from aspects of structural diversity and identification, bioactivities, and biotechnological production. New strategies to discover novel C-glycosides and CGTs, as well as the applications of biotechnological methods to produce C-glycosides in the future are also discussed.


C-glycosyltransferases Biotechnological Production Sugar Moiety Structural Diversity Aspects Of Diversity Structural Identification Green Approaches Great Diversity Wide Distribution Significant Activities

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